The puppets obviously make Thunderbirds and the others what they are, but who can forget those sound effects? The noise of the engines spinning up on those legendary vehicles, or the meaty, realistic and mechanical sounds that set the show apart from a cartoon. And that part was played out on an unassuming Handsworth Wood road. Much of the Andersons' work was filmed in Berkshire, but Birmingham had a part to play in all of them. New book Dirty Stop Out's Guide To Brum captures the city's nightlife in the 1970s.Amazing images show how loved the old Birmingham trams were.Then, the biggy - Thunderbirds, which is still iconic nearly 6 decades later. Stingray followed in glorious technicolour, joining the crew of a chromed submarine exploring the deep sea. Then we saw Fireball XL5, and the World Space Force that protected Earth from their Pacific island base. As the 60s rolled around, Gerry and Sylvia Anderson of the Supermarionation studio were preparing their next puppet projects that would blow the world of TV entertainment wide open.įirst came Supercar, with Mike Mercury and his go-anywhere, do-anything space age vehicle.
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Pharmacokinetic profiles were fitted to an extended parent-metabolite pharmacokinetic model, based on a two-compartment model, and the pharmacodynamic effects of the agents were fitted to a platelet aggregation effect model that consisted of the following parameters: Ks, the active-form platelet synthesis rate constant K, the apparent reaction rate constant of the agent and active-form platelets Kel-PRP, the apparent rate constant of platelets and ε, an intrinsic activity parameter. Time courses of plasma concentrations of the antiplatelet agents and their platelet aggregation effects were analysed using ADPAT V. The drugs chosen are used widely and reflect various mechanisms of antiplatelet agents. We used triflusal, cilostazol and clopidogrel for the development of a semi-mechanistic PK/PD model. We examined the relationships between plasma concentrations of antiplatelet agents (triflusal, clopidogrel and cilostazol) and the platelet aggregation inhibitory effect after dosing. 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